Mahmoud Moustafa, DVM, PhD

I am a veterinary oncologist with extensive expert in design, conduct, monitor, and successfully carry out cross-disciplinary research. I have a broad background in development of translational in-vivo models, with specific training and expertise in Radiation Oncology.

The overarching aim of my research area “Molecular- and Translational RadioOncology” is to further improve personalized oncology by integrating state-of-the-art biological, molecular biophysical, medical, and computational technological science.

My research interest’s focus mainly on tumor growth and normal tissue toxicity in laboratory animal models, in response to radiotherapy (RT).

1. My early publications directly addressed the measurement of relative biological effectiveness (RBE) of photon and high-LET particle irradiation in vivo, including but not limited to different syngeneic orthotopic tumor models (e.g. lung, pancreas, brain) both with genetically engineered mouse models (GEMM) as well as patient derived xenografts (PDX).


2. My work centers also on the measurement of RBE for particle irradiation with protons, helium-, carbon and oxygen ions available at HIT for development of late normal lung tissue toxicity or complications (pulmonary fibrosis) by utilizing a novel non-invasive CT imaging based Fibrosis Index (FI) model.


3. In addition to the contributions described above, with a team of collaborators, I am leading the HIT animal facility for conducting in vivo studies including high-precision irradiation of tumors and whole thorax of laboratory animals. In addition, I provide support for verification of tested dose using positron-emission-tomography (PET) imaging and conduct small animal surgery e.g. orthotopic tumor implantation (Lung, pancreas, brain), surgical resection of lung, heart, and organ perfusion.

Disclosures: