Main Session
Sep
28
PQA 04 - Breast Cancer, Patient Reported Outcomes/QoL/Survivorship, Functional Radiation Medicine, Hematologic Malignancies, Palliative Care, and International/Global Oncology
2817 - Low-Dose Electron Beam Radiotherapy in the Treatment of Peyronie's Disease: Evaluation of Tolerance and Efficacy
Presenter(s)
Agnieszka Namysl-Kaletka, MD, PhD - Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, slaskie
A. J. Namysl-Kaletka1, I. Debosz-Suwinska2, A. Roch-Zniszczol1, S. Blamek3, W. Majewski1, M. Gajek1, D. Gräupner2, A. Misiorowska-Golosz1, B. Goc1, and J. Wydmanski3; 1Department of Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Poland, Gliwice, Poland, 2Department of Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland, 3Department of Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch., Gliwice, Poland
Purpose/Objective(s):
Peyronie's disease is a rare condition characterised by the formation of fibrous plaques within the tunica albuginea of the penis, leading to penile deformity, curvature, and consequently painful erections. The use of low-dose radiotherapy may be a valuable treatment option. The purpose of the study is to evaluate the efficacy and tolerance of radiation therapy in men diagnosed with Peyronie's disease.Materials/Methods:
Thirty patients treated with electron-based radiation therapy were retrospectively analysed. A total dose of 12 Gy was administered in six fractions in all cases. The degree of curvature, the presence of fibrous plaques, pain during erection assessed on the NRS scale, and improved sexual function were taken into account.Results:
The median age was 57.5 years (22÷72 years). Before radiotherapy, all patients had penile curvature ranging from 10-70 degrees, with a median duration of symptoms of 6 months (2÷36). Sixty-three percent of the patients experienced pain during erection on an NRS scale of 5 (range 2÷7), which resulted in erectile dysfunction in 10% of the patients, and erectile difficulties in 43%. Eighty-seven percent had palpable plaque with a median maximum diameter of 15 mm( range 4÷40) . Seventy-seven percent had no prior treatment. Five patients received oral vitamin E before radiation therapy and two received corticosteroid injections. Median follow-up after the end of treatment was12 months (1÷81). Only one patient experienced an acute radiation reaction, grade 1 skin redness according to the NCI CTCAE scale. 67% of the patients achieved clinical improvement, while 23% remained stable; only 10% (3pts) experienced worsening. Pain reduction was observed in 47% of the group, with 37% achieving complete resolution, which was associated with an improvement in sexual function. Progression of curvature (3%) or fibrosis (6%) was rare. Among them, one patient experienced a relapse of the disease 47 months after treatment in the form of pain on the NRS scale 3, during erection 6, after complete resolution of pain and fibrosis after radiotherapy.In the second patient, the curvature worsened and the patient was scheduled for repeated electron beam radiation therapy to a total dose of 12 Gy in 6 fractions. Two months after radiotherapy, a 20% improvement was observed and after seven months the improvement reached 50%. Early follow-up data showed a 58% improvement at one month and further clinical gains at four months for most patients.Conclusion:
Low-dose electron beam radiotherapy is a safe and effective treatment for Peyronie's disease. It is beneficial for relieving symptoms and inhibiting further progression, leading to a significant improvement in sexual function.