3015 - A Phase I Clinical Study of Topical Taurine in Preventing Acute Radiation Dermatitis in Breast Cancer Patients Undergoing Adjuvant Radiotherapy

Purpose/Objective(s):

Materials/Methods: This study collected patients' basic information and medical history and initiated topical taurine solution treatment when skin inflammation occurred. During treatment, the Skin Toxicity Assessment Tool (STAT) was used to evaluate changes in subjective symptom scores, and objective indicators such as radiation areas were recorded. At the same time, possible adverse reactions were monitored. The concentration of taurine solution was 5%, diluted with 0.9% physiological saline, with an initial concentration of 16mmol/L, and the dose was gradually increased using the modified Fibonacci method. Based on the "3+3 dose escalation design", the study evaluated whether to enter the next dose group. The toxicity was graded using the NCI CTCAE 5.0 standard, and adverse events exceeding grade 1 were considered dose-limiting toxicities (DLT). The maximum tolerated dose (MTD) was defined as the dose level that induced DLT.

Results: Topical taurine treatment for acute radiation-induced skin injury showed significant efficacy in alleviating various symptoms. Before treatment, patients had high scores for symptoms such as itching, pain, burning sensation, pulling sensation and tenderness. After taurine treatment, all symptoms improved significantly in the first and second weeks. Specifically, the itching score decreased from 2.2 to 0.75 and 0.8, the pain score decreased from 0.95 to 0.3 and 0.25, the burning sensation score decreased from 1.6 to 0.5 and 0.55, the tenderness score decreased from 1.8 to 0.9 and 0.7, and the tightness score decreased from 1 to 0.65 and 0.85. These symptoms continued to improve over the two weeks after radiotherapy, especially itching and pain, which were significantly alleviated, further demonstrating the effectiveness of taurine in relieving radiation dermatitis.

Conclusion: After topical taurine treatment, patients' scores for symptoms such as itching, pain, burning sensation, pulling sensation and tenderness decreased significantly, especially in the first and second weeks of treatment, when symptoms were effectively relieved. Follow-up results showed that symptoms continued to improve after radiotherapy. Taurine, as a safe and effective treatment, can significantly alleviate clinical symptoms of radiation dermatitis and shows good application prospects.