3154 - Macroscopic and Microscopic Assessment of the Proton-CAT for Practical Radiation Therapy Applications Using a Planning Tool Simulation
Presenter(s)
J. Wu1,2, W. Xianliang3, L. Shun4, and H. Zhimin5; 1Sichuan Cancer Hospital, Chengdu, China, 2Sichuan Cancer Hospital and Research Institute, University of Electronic Science and Technology of China, Chengdu, China, 3Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, 610041, China, 4Sichuan Cancer Hospital and Research Institute, University of Electronic Science and Technology of China, Radiation Oncology Department, Chengdu, China, 5Key Laboratory of Radiation Physics and Technology of Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, China
Purpose/Objective(s): In this study, we introduced a novel and promising proton therapy for tumors, called nitrogen-targeting-Proton-Carbon-Alpha-Therapy (Proton-CAT) and to assess the effectiveness of this new approach using a planning tool simulation at both the macroscopic and microscopic level.
Materials/Methods:
Proton-CAT is based on the stable isotope nitrogen-15 is irradiated with proton to produce alpha particles and recoiling 12C ions. The MC codes of a simulation toolkit was employed to derive all dosimetric data of the proton-CAT. In the macroscopic calculations, we creating 24-32 MeV proton Spread-Out Bragg Peak (SOBP) with a modulation width of 3.0 mm, irradiated into a tissue equivalent (TE) phantom with and without 15N material. Energy deposition of protons, alpha particles and 12C ions were scored along the path of the beam. In the microscopic calculation, in order to evaluate the energetic particles’ (12C ions and a-particles) implantation damage to the tumor cells in Proton-CAT and boron neutron capture therapy (BNCT) technologies, the cell model was used.Results:
The results demonstrate the advantages of Proton-CAT, which the average increment of energy deposit of 12C ions and a-particles were 26.1% and 204.9%, compared to conventional proton therapy in the SOBP region. Moreover, the energy deposition in cell nucleus of Proton-CAT can achieve results (3.38 keV·µm-3) similar to those of BNCT (3.44 keV·µm-3).Conclusion:
Our findings support the theory that this method has the potential to enhance the biological effectiveness of proton beam, due to the a particles and 12C ions produced from the nuclear reactions involved.