3115 - Unveiling the Burden of Cervical Cancer in Egypt: Incidence Trends, HPV Association, and the Urgent Need for Prevention

05:00pm - 06:00pm PT

Hall F

Screen: 31

POSTER

Presenter(s)

Ahmed Nawwar, MD, MPH - University of Kansas Medical Center, KC, KS

A. E. Nawwar^1,2, M. Abdelhalim³, M. Y. El-mezayen⁴, B. El Sabaa⁴, N. Hegazy⁴, A. A. ElSaid⁵, and E. Sheta⁴; ¹Kansas University Medical Center, Kansas city, KS, ²Harvard T. H. Chan School of Public Health, Boston, MA, ³Clinical Oncology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt, ⁴Faculty of Medicine Alexandria University, Alexandria, Egypt, ⁵Clinical Oncology and Nuclear Medicine Department, Alexandria University, Alexandria, Egypt

Purpose/Objective(s):

The purpose of this study is to assess cervical cancer incidence trends in Alexandria and evaluate the relationship between HPV infection and histopathological subtypes. The primary objectives are to (1) estimate the incidence of cervical cancer using data from the last 10 years, (2) analyze the distribution of Squamous Cell Carcinoma (SCC) and Adenocarcinoma, and (3) determine the association between HPV infection and cancer type to guide future screening and vaccination initiatives in Egypt.

Materials/Methods:

A retrospective cross-sectional analysis was conducted using hospital records of patients diagnosed with cervical cancer in the last ten years. Data on age, histological type (Squamous Cell Carcinoma [SCC] vs. Adenocarcinoma) and HPV association were collected. Incidence rates were calculated per 100,000 women in the last four years. Descriptive statistics were used to summarize patient characteristics. An independent sample t-test assessed age differences between SCC and Adenocarcinoma patients, while a Chi-square test evaluated the association between HPV status and histological type. Statistical analysis was performed using statistical software.

Results:

A total of 187 cases were identified, with yearly incidence rates per 100,000 women of 2.33 in 2024, 2.55 in 2023, 1.44 in 2022, and 1.77 in 2021, resulting in an average incidence of 2.03. The mean age of patients was 53.4 ± 13.3 years, with the majority falling within the 40-50 age group. SCC accounted for 83.4% (n=156) of cases, while Adenocarcinoma comprised 14.4% (n=27). Chi-square test revealed a significant association between HPV status and cancer type (?² = 17.49, p = 0.042). Independent t-test revealed no statistically significant difference in age between SCC (M = 53.13, SD = 13.75) and Adenocarcinoma patients (M = 55.22, SD = 11.14), t = -0.75, p = 0.45.

Conclusion:

This study highlights the increasing incidence of cervical cancer in Alexandria, with SCC as the predominant histological subtype and a significant association with HPV infection. The findings underscore the urgent need for a structured national screening program and HPV vaccination initiative to reduce the disease burden in Egypt. The low screening rates and lack of national recommendations present significant challenges to early detection and prevention. Expanding data collection, improving HPV testing accessibility, and addressing barriers to screening are essential steps toward developing an effective, evidence-based cervical cancer prevention strategy.