3621 - A Simulation Study on the Optimization of Precise Navigation for Transcranial Focused Ultrasound Tumor Treatment Using a Single-Element Transducer
Presenter(s)
P. Gao1, Y. Sun2, G. Zhang1, and L. Wang1,3; 1Artificial Intelligence Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China, 2Department of Biomedical Engineering, Shenyang University of Technology, Shenyang, China, 3Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China
Purpose/Objective(s): Low-intensity focused ultrasound induces tumor cell death through localized and non-invasive mechanical disruption of tumor cells. However, precise navigation of focused ultrasound in clinical treatment remains an internationally recognized challenge. The current use of focused ultrasound for single-element lacks precision in determining the optimal position, with placement typically perpendicular to the skull as the default approach.
Materials/Methods: A three-dimensional spatial model was reconstructed using brain CT images from 10 of the 25 patients, with a slice thickness of 1 mm. By aligning attenuation parameters, an ultrasound attenuation model was established, targeting specific regions along the inner edge of the temporal lobe for localization analysis. Furthermore, skull thickness and orientation angles were computed from CT images and incorporated into three distinct optimization algorithms designed to enhance computational efficiency. The effectiveness of these optimization algorithms was rigorously validated through comparative analyses with control results obtained across varying frequencies.
Results: The optimization method efficiently eliminated numerous superfluous data points to ensure the utmost time efficiency. Through the implementation of these methods, a remarkable reduction of at least 70% in computation time has been achieved, all while ensuring a treatment effect of no less than 0.97 ± 0.02. The optimal stimulation statistics for the 10 patients presented in Table 1, where two individuals over 50 years of age achieved optimal results with vertical stimulation at all frequencies.
Conclusion: The new optimization method demonstrated remarkable enhancements in computational efficiency, while ensuring the preservation of the original treatment efficacy. Vertical treatment presented as a potential approach solely applicable to elderly individuals exhibiting lower skull density ratios.
Abstract 3621 - Table 1: Optimal stimulation statistic
| Frequence 1 | Frequency 2 | |
| Age | 51.50±15.36 | |
| Distance to target region (mm) | 26.35±0.55 | 29.57±1.33 |
| Angle with three directional planes (°) | 94.51±12.00 | 90.27±13.40 |
| 170.09±10.07 | 172.39±11.05 | |
| 92.82±5.88 | 90.41±2.54 | |
| Skull density ratio | 0.61±0.09 | 0.58±0.05 |
| Peak sound pressure ratio (Freq 2 /Freq 1) | 0.44±0.10 | |