Claire Vanpouille-Box, PhD

Claire Vanpouille-Box is an Assistant Professor of Cell Biology in Radiation Oncology. She developed a keen interest in anti-cancer treatments based on the combination of immunotherapy and radiation therapy (RT). Her graduate work at the University of Angers (France), studied a new treatment concept that aims at generating a localized RT via the use of nanoparticles during which she became interested in radiation-induced anti-tumor immunity.

She then conducted her postdoctoral training at NYU School of Medicine and at Weill Cornell Medicine whose preclinical studies demonstrated that TGFb is a master regulator of RT-induced anti-tumor immunity and that RT-induced cancer-cell type I interferon is required to elicit durable regression of the irradiated and non-irradiated tumor (i.e., the abscopal effect).

In 2019, she has been appointed Assistant Professor of Cell Biology in Radiation Oncology by the Department of Radiation Oncology at Weill Cornell Medicine. As an independent investigator, her research focus evolved to leverage her previous experience to investigate the key factors impacting the immunogenicity of radiotherapy in glioblastomas (GBM). More specifically, she aims at exploring the immune-metabolic role of radiation therapy and to define the impact of TGFb and activin A in the radiation response of GBM.

Claire has received many prestigious awards among which the 2014-Marie Curie Award from the Radiation Research Society and the 2015-AACR Susan G Komen Scholar-in-training award from the American Association for Cancer Research.

She serves as associate editor for Radiation Research and is section editor of “Immune RadioBiology” for the Journal of Translational Medicine.

Disclosures: