MODERATOR(S)
Leslie Chang, MD - University of Minnesota
session DESCRIPTION
Patients with cancer predisposition syndromes are at increased risk for developing aggressive bone and soft tissue sarcomas during childhood and young adulthood. Curative treatment frequently requires multimodality therapy, including surgery, chemotherapy and radiation therapy. In this population, radiation decision making is particularly complex, requiring clinicians to balance the immediate risk of sarcoma-related morbidity and mortality against a lifelong, genetically mediated risk of radiation-induced secondary malignancies. The session will begin with an overview of cancer predisposition syndromes, followed by two case-based discussions. A case of NF1-associated malignant peripheral nerve sheath tumor will highlight considerations for preoperative radiation, pediatric versus adult planning differences, and outcome data with and without radiation. A second case focusing on Li-Fraumeni-associated soft tissue sarcoma will emphasize radiation modality selection and techniques to minimize normal tissue exposure. Attendees will gain practical, evidence-based strategies to support safe and effective radiation therapy for this high-risk patient population. This session is co-sponsored by the sarcoma and pediatric cancer education tracks.
learning objectives
- Compare survival and local control outcomes with and without radiation in children and young adults with cancer predisposition syndromes.
- Characterize differences between preoperative and postoperative radiation for patients with cancer predisposition syndromes.
- Describe techniques to minimize radiation of normal tissues, including use of proton therapy, in this patient population.
Credits
| AMA PRA Category 1 Credits: | 1.00 |
Presentations
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08:00am - 08:02am ETSpeaker: Leslie Chang, MD - University of Minnesota, Minneapolis
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08:02am - 08:17am ETSpeaker: Christine Pratilas, MD - Johns Hopkins University, Baltimore
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08:17am - 08:32am ETSpeaker: Sahaja Acharya, MD - Johns Hopkins University School of Medicine, Baltimore
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08:32am - 08:47am ETSpeaker: Stephanie Schaub, MD - University of Washington, Seattle
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08:47am - 09:00am ETSpeaker: Leslie Chang, MD - University of Minnesota, Minneapolis