EDU 20 - ASTRO Radiation Therapy for WHO Grade 4 Adult-Type Diffuse Glioma Guideline: A Case-Based Interactive Discussion
MODERATOR(S)
Debra Yeboa, MD - MD Anderson Cancer Center
Joseph Bovi, MD - Medical College of Wisconsin
session DESCRIPTION
World Health Organization (WHO) grade 4 adult-type diffuse glioma remains one of the most challenging malignancies to treat, demanding a multidisciplinary and evidence-based approach. The role of radiation therapy (RT) has evolved since the publication of the 2016 ASTRO Guideline on Radiation Therapy for Glioblastoma with this guideline serving as a replacement. This session will provide an in-depth overview of the updated guidance, highlighting key changes in molecular diagnostics, RT protocols and systemic therapies. Attendees will gain practical insight for implementing the guideline, with case-based discussions demonstrating how to tailor treatment strategies to individual patients. Emphasis will also be placed on optimizing care pathways and fostering collaboration among neurosurgeons, neuro-oncologists, radiation oncologists and supportive care teams to enhance outcomes. This session is essential for clinicians seeking to stay at the forefront of WHO grade 4 diffuse glioma management and ensure their patients benefit from the latest evidence-based strategies. Whether you are a seasoned specialist or new to neuro-oncology, this education session will equip you with actionable knowledge to improve patient care in this rapidly evolving field.
learning objectives
- Discuss indications and appropriate techniques for reirradiation in patients with grade 4 diffuse gliomas whose disease recurs following completion of standard first-line therapy.
- Identify indications for postoperative RT and postoperative chemoradiation and discuss the evidence for appropriate dose-fractionation regimens for external beam radiation therapy (EBRT) after biopsy/resection in patients with WHO grade 4 adult-type diffuse gliomas and how might treatment vary based on pretreatment characteristics.
- Discuss appropriate target volumes and techniques for definitive EBRT.
Credits
| AMA PRA Category 1 Credits: | 1.25 |
Presentations
-
10:45am - 12:00pm PT
ASTRO Radiation Therapy for WHO Grade 4 Adult-Type Diffuse Glioma Guideline: A Case-Based Interactive Discussion
Speaker: Joseph Bovi, MD - Medical College of Wisconsin, Milwaukee -
10:45am - 12:00pm PT
ASTRO Radiation Therapy for WHO Grade 4 Adult-Type Diffuse Glioma Guideline: A Case-Based Interactive Discussion
Speaker: Debra Yeboa, MD - MD Anderson Cancer Center, Houston -
10:45am - 10:47am PT
Introductions
Speaker: Debra Yeboa, MD - MD Anderson Cancer Center, Houston -
10:47am - 11:02am PT
Systemic Therapy and/or Adjunctive Therapies (Alternating electric Field Therapy); Indications for Postoperative RT and Postoperative Chemoradiotherapy
Speaker: Kristin Redmond, MD, MPH - Johns Hopkins University, Baltimore -
11:02am - 11:17am PT
Dose-fractionation Regimens for EBRT After Biopsy/Resection; Treatment Variation Based on Pretreatment Characteristics
Speaker: Jonathan Knisely, MD, FASTRO, FASTRO - Weill Cornell Medicine, New Haven -
11:17am - 11:32am PT
Target Volumes and Techniques for Definitive EBRT
Speaker: Mary Frances McAleer, MD, PhD - MD Anderson Cancer Center, Houston -
11:32am - 11:47am PT
Indications and Appropriate Techniques for Reirradiation
Speaker: Christina Tsien, MD, FASTRO - McGill University Health Centre, Bethesda -
11:47am - 12:00pm PT
Questions and Answers
Speaker: Joseph Bovi, MD - Medical College of Wisconsin, Milwaukee