MODERATOR(S)
Jeremy Setton, MD - Memorial Sloan Kettering Cancer Center
session DESCRIPTION
Metastasis-directed radiotherapy (RT) has moved from an end-of-life palliation tool to an integral component of oligometastatic and oligoprogressive management. Yet the field still lacks an integrated biological framework to predict when RT will change the metastatic trajectory versus merely debulk an index lesion. This session will translate emerging mechanistic data into clinically actionable insights across three domains: (i) metastatic states and microenvironmental dependencies that shape sensitivity to local ablation; (ii) immunologic consequences of RT in metastatic disease, including effects on T-cell priming, myeloid programs and lymphatic architecture that influence systemic control and interactions with immunotherapy; and (iii) chromosomal instability-driven inflammatory signaling that promotes metastatic fitness and may be amplified or therapeutically exploited by RT-induced DNA damage. Through expert talks and interactive audience polling, attendees will learn how these emerging mechanistic insights will dictate the future use of radiotherapy to modify the trajectory of metastatic disease to benefit patients. The goal is to move from data to dialogue, equipping radiation oncologists and trialists to communicate and deliver RT's value in metastatic care with greater biological precision.
learning objectives
- Elucidate the role of radiotherapy in modifying clinical trajectory of oligometastic and oligoprogressive disease.
- Understand the positive and negative immunologic consequences of radiotherapy on the trajectory of metastatic cancer.
- Understand the interaction of chromosomal instability and radiotherapy on cellular signaling.
Credits
| AMA PRA Category 1 Credits: | 1.00 |
Presentations
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05:00pm - 05:02pm ETSpeaker: Jeremy Setton, MD - Memorial Sloan Kettering Cancer Center, New York
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05:02pm - 05:17pm ETSpeaker: C Jillian Tsai, MD, PhD, MS - Princess Margaret Cancer Centre, Toronto
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05:17pm - 05:32pm ETSpeaker: Sean Pitroda, MD - University of Chicago Medical Center, Chicago
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05:47pm - 06:00pm ETSpeaker: Jeremy Setton, MD - Memorial Sloan Kettering Cancer Center, New York