MODERATOR(S)
Yue Yan, DSc, PhD - Dartmouth Hitchcock Medical Center
session DESCRIPTION
Functional imaging is rapidly moving from "better pictures" to actionable biology that can shape what we treat, how much dose we prescribe, and when we adapt during a course of radiation therapy. This extended session will provide a deep dive into the current state of functional imaging guided radiation therapy across cancer sites, including but not limited to lung, head and neck, prostate and brain. We will highlight established roles for PET and CT in target definition, focal dose escalation, and response adapted management, and emerging approaches that integrate functional MRI techniques such as diffusion, perfusion and spectroscopy to characterize intratumoral heterogeneity and support biologically informed adaptation. The session will also cover functional normal tissue assessment and avoidance strategies across organs at risk, emphasizing how quantitative imaging can help preserve organ function while maintaining tumor control. Finally, an expert panel will focus on practical barriers and future directions, including standardization and quality assurance, uncertainty quantification, image registration and segmentation, workflow integration, and clinical trial designs needed to demonstrate benefit and accelerate safe adoption.
learning objectives
- Summarize the current clinical indications and evidence base for functional imaging guided radiation therapy across multiple cancer sites, including applications for target definition, focal dose escalation, and response adapted management.
- Identify key technical, workflow and standardization requirements needed to implement functional imaging guided planning and adaptation, and to design studies that rigorously evaluate safety and clinical benefit.
Credits
| AMA PRA Category 1 Credits: | 1.00 |
Presentations
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10:45am - 10:47am ETSpeaker: Yue Yan, DSc, PhD - Dartmouth Hitchcock Medical Center, Lebanon
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10:47am - 11:07am ET
Adaptive Radiation Therapy for Glioblastoma and the Potential for Advanced Imaging to Guide Response on Treatment
Speaker: Arjun Sahgal, MD - Sunnybrook Health Sciences Centre, Toronto -
11:07am - 11:27am ETSpeaker: Bin Han, PhD - Stanford University, Palo Alto
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11:27am - 11:47am ET
Habitat Escalated Adaptive Therapy (HEAT): A Phase 2 Trial Utilizing Radiomic Habitat-Directed and Genomic-Adjusted Radiation Dose (GARD) Optimization for High-Grade Soft Tissue Sarcoma
Speaker: Arash Naghavi, MD, MS - H. Lee Moffitt Cancer Center and Research Institute, Tampa -
11:47am - 12:00pm ETSpeaker: Yue Yan, DSc, PhD - Dartmouth Hitchcock Medical Center, Lebanon