International 03 - Global SFRT Practice: Mapping Evidence Gaps for Successful Clinical Implementation
MODERATOR(S)
May Abdel-Wahab, MD, PhD, FASTRO - Iaea
session DESCRIPTION
This session will examine the future of Spatially Fractionated Radiation Therapy (SFRT) from European, American and international perspectives. It will address the evolving needs and competencies required to treat locally advanced malignant tumors and to palliate large, resistant malignancies. Experts representing the European Society for Radiation Oncology (ESTRO), American Society for Radiation Oncology (ASTRO), Low- and Middle-Income Countries (LMIC), and the International Atomic Energy Agency (IAEA) will share their unique insights on various SFRT techniques, including GRID, LATTICE, MLC-based approaches, and the most advanced PATHY method. The discussion will explore emerging trends in treating bulky tumors, particularly the potential to harness the abscopal effect, where localized irradiation triggers an immune response and mediates systemic antitumor effects. This phenomenon — primarily driven by cellular-mediated immunity — has become a major focus in tumor regression research. Evidence shows that single-fraction, high-dose radiation therapy can significantly delay the growth of both local and distant tumors. Preclinical studies, such as those using the LLC xenograft model, demonstrate that lattice high-dose radiation increases inflammatory cytokine secretion and enhances CD3+ T-cell infiltration in irradiated tumors.
learning objectives
- Gain a comprehensive understanding of current gaps and clinical evidence-based practices for developing sustainable, inclusive and future-ready global SFRT programs.
- Deepen their understanding of the biological basis and Physics innovative technology for SFRT dose delivery and addressing the heterogenicity of the literature data.
- Explore strategies to translate these innovative techniques and gap analysis for better Implementing SFRT in resource-limited settings.
Credits
| AMA PRA Category 1 Credits: | 1.00 |
Presentations
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03:00pm - 03:02pm ETSpeaker: May Abdel-Wahab, MD, PhD, FASTRO - Iaea, Vienna
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03:02pm - 03:17pm ETSpeaker: Slavisa Tubin, - University Clinic Krems Universitätsklinikum, vienna
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03:17pm - 03:32pm ETSpeaker: Heng Li, PhD - Johns Hopkins University School of Medicine, Baltimore
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03:32pm - 03:47pm ETSpeaker: Soha Ahmed Salem, MD, MBA - Childrens Cancer Hospital Egypt, Cairo
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03:47pm - 04:00pm ETSpeaker: May Abdel-Wahab, MD, PhD, FASTRO - Iaea, Vienna