SS 38 - Radiation and Cancer Biology 4: Immunometabolism

Presentations

• 12:45pm - 02:00pm PT

  Radiation and Cancer Biology 4: Immunometabolism

  Speaker: Adam Mueller, MD, PhD - UPMC Cancer Center, Pittsburgh
• 12:45pm - 02:00pm PT

  Radiation and Cancer Biology 4: Immunometabolism

  Speaker: Aparna Kesarwala, MD, PhD - Emory University School of Medicine, Atlanta
• 12:45pm - 12:55pm PT

  Lactate-Induced DNMT1 Lactylation in Dendritic Cells Epigenetically Silences STAT1 to Suppress Antigen Presentation and Drive Radioresistant Tumor Immune Evasion

  Speaker: Weitao Wen, - Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical, Jinan
• 12:55pm - 01:05pm PT

  Radiation Activates the AIM2 Inflammasome to Enhance Immunotherapy by Triggering IL-1ß Signaling and DC Activation in Colorectal Cancer

  Speaker: Shujuan Zhou, MD - Department of Radiation Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai
• 01:05pm - 01:15pm PT

  Cholesterol Flux Rewiring through LDLR Palmitoylation Establishes a Mitochondrial Shield and Immune Desert in Radioresistant Tumors

  Speaker: Weidong Zhong, - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
• 01:15pm - 01:25pm PT

  Hypoxanthine Enforces Cytotoxic CD8⁺ T Cells via Purine Salvage Synthesis and Epigenetic Modification to Potentiate Immunotherapy

  Speaker: Jiacheng Wang, - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
• 01:25pm - 01:35pm PT

  Low-Dose Radiotherapy Modulates Dendritic Cell Metabolism to Reprogramme the Tumor Immune Microenvironment

  Speaker: Yuntao Zhou, - Tianjin Medical University Cancer Institute & Hospital, Tianjin
• 01:35pm - 01:45pm PT

  Discussant

  Speaker: Stephen Shiao, MD, PhD - Cedars-Sinai Medical Center, Los Angeles