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8:30 AM - 8:40 AM PT

180 - Multi-Institutional Validation of the SHIELD-RT Machine Learning Model to Prevent Acute Care Events during Radiotherapy
Speaker: Elia, Marianna, MS - University of California San Francisco, San Francisco, CA
8:40 AM - 8:50 AM PT

181 - Validation of a Digital Twin-Based Clinical Trial Design Approach Combining Radiotherapy and Tyrosine Kinase Inhibitors: Prospective Virtual Trial Predictions Match Real-World Data
Speaker: McClatchy, David, PhD - Massachusetts General Hospital, Boston, MA
8:50 AM - 9:00 AM PT

182 - Predictive Modeling Radiation-Induced Visual Field Deficits for Early Toxicity Detection
Speaker: Pham, Thao-Nguyen - Radiation Oncology Department, Centre François Baclesse, Caen, Normandy, France, CAEN
8:00 AM - 8:10 AM PT

183 - 10-Year Neuropsychological and QoL Outcomes in Pediatric Brain Tumor Survivors: A Comparison of Photon and Proton Cohorts
Speaker: Yock, Torunn, MD, FASTRO, MCH - Massachusetts General Hospital, Boston, MA
8:10 AM - 8:20 AM PT

184 - Growth Outcomes Following Vertebral Body Sparing Proton CSI for Pediatric Brain Tumors: A Multicenter, Combined Prospective - Retrospective Cohort Study
Speaker: Ioakeim-Ioannidou, Myrsini, MD - Massachusetts General Hospital, Boston, MA
8:20 AM - 8:30 AM PT

185 - Low Rates of Marginal Failure in Pediatric Patients Treated with Pencil Beam Scanning Proton Therapy: Results from a Single Institution Phase IV Surveillance Trial
Speaker: Roubil, John, MD - Massey Cancer Center, Richmond, VA
8:30 AM - 8:40 AM PT

186 - Characterizing Radiation Target Volumes and Patterns of Failure in Pediatric Neuroendocrine Tumors Using <sup>68</sup>Ga DOTA-Octreotate PET/CT
Speaker: McKone, Elizabeth, MD - Mayo Clinic Rochester, Rochester, MN
8:40 AM - 8:50 AM PT

187 - A Phase IV Surveillance Trial of Pencil Beam Scanning Proton Therapy in Children
Speaker: Lucas, John, MD, MS - St. Jude Childrens Research Hospital, Memphis, TN
8:00 AM - 8:10 AM PT

188 - RC48-ADC Combined with Radiotherapy and Immunotherapy as Salvage Therapy for Advanced Solid Tumors with HER2 Expression: A Multicenter, Phase II Trial
Speaker: Xu, Meiling, MD, PhD, RT - The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu
8:10 AM - 8:20 AM PT

189 - Single-Cell RNA Sequencing to Reveal Cellular Mechanisms Driving Differential Responses to Radiotherapy Combined with Systemic Therapy and Immunotherapy in MSS Locally Advanced Rectal Cancer with vs. without Liver Metastases
Speaker: Wang, Yaqi, MD - Fudan University Shanghai Cancer Center, Shanghai, Shanghai
8:20 AM - 8:30 AM PT

190 - Single-Cell Profiling Reveals Dynamics TIME Remodeling after Neoadjuvant Radiotherapy followed by Chemotherapy and Immune Checkpoint Blockade in pMMR/MSS LARC
Speaker: Chen, Yinan, PhD - Cancer Hospital,Chinese Academy of Medical Sciences, Beijing, Beijing
8:30 AM - 8:40 AM PT

191 - Preclinical Evaluation of First-in-Class PROTAC Survivin Degrader HMAK101 for Radiosensitization for GBM, DIPG and Brain Metastases
Speaker: Zheng, Shuhua, DO, PhD - Northwestern Feinberg School of Medicine, Chicago, IL